The Pros and Cons of Hormone Pellet Therapy: Everything You Need to Know

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Charles Mok

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pros and cons of hormone pellets

Hormone pellet therapy for sustained hormone release 

Hormone imbalance can cause frustrating symptoms that disrupt your quality of life. Hot flashes, night sweats, low libido, and mood swings are just some of the issues that may arise during perimenopause, menopause, and andropause. Hormone pellet therapy could help restore your hormonal balance and relieve these symptoms.

What is Hormone Replacement Therapy and What are the Different Types?

Hormone replacement therapy (HRT) involves replacing hormones that decline with age or due to medical conditions. The goal is relieving unpleasant menopausal symptoms and preventing long-term health risks like osteoporosis. 

There are a few main types of hormone replacement therapy:

  • Estrogen Therapy: Taking estrogen alone or with progesterone if you have a uterus. This comes as pills, patches, gels, creams and vaginal rings/tablets.
  • Estrogen and Progestin Therapy: A combination therapy with both estrogen and progestin for women with a uterus to protect the uterine lining. Available as pills, patches and rings.
  • Testosterone Therapy: Testosterone supplements may be added for women with low testosterone. Options include gels, patches, tablets or injections.

Discover personalized Hormone Replacement Therapy solutions at Allure Medical – Take the first step towards a healthier you!

Methods for Administering Hormone Therapy

HRT can be administered in various ways:

Delivery MethodDescription
PillsOral pills containing estrogen and progesterone are swallowed and absorbed through the digestive tract. Effectiveness can vary based on stomach contents, liver metabolism and other factors.
PatchesPatches applied to the skin (torso, buttocks, arm) deliver hormones directly into the bloodstream, bypassing the digestive system. Patches are replaced regularly such as weekly.
TopicalsTopical gels or creams applied daily to the arms, legs or abdomen allow absorption of hormones through the skin. Dosing is flexible but absorption depends on skin health and area.
InjectionsHormones injected into muscle/fat with a syringe allow for precise dosing and provider monitoring. Injections are given every 1-2 weeks.
PelletsPellets surgically implanted under the skin release consistent hormones over months as they slowly dissolve. No frequent dosing needed but requires replacement surgery every few months.

How Do Hormone Pellet Implants Work?

Hormone pellets are small rods made of compressed hormones like estrogen, testosterone, or a combination. The pellets are implanted under the skin – usually in the hip or buttocks. A doctor makes a small incision and inserts the pellets using a trochar and cannula tool. Local anesthesia is used to numb the area first.

Once implanted under the skin, the pellets slowly dissolve and release hormones steadily into the bloodstream over 3-6 months typically. This provides stable hormone levels, unlike pills or creams that fluctuate. The steady hormone release avoids peaks and valleys.

The pellet implantation procedure takes about 10-15 minutes in a doctor’s office. Only a small incision is needed. The pellets dissolve completely over time, so nothing needs removal later.

Over months, the hormone levels will decline as the pellets dissolve. The pellets will need replacement every 3-6 months or so, depending on the individual. This is considered bioidentical hormone replacement as the hormones match the natural hormones in the body closely.

Advantages of Hormone Pellet Therapy

Hormone pellet therapy offers a number of unique benefits over other forms of hormone replacement for both men and women. These include

Stable Hormone Levels

The hormones released from the pellets maintain more stable blood levels than pills, patches, gels or creams. The steady hormone delivery avoids the fluctuations and peaks and valleys characteristic of other delivery methods. This leads to better control of symptoms and reduces side effects associated with spiking or dropping hormone concentrations.

Long-Lasting Effects

The hormone pellets typically only need to be replaced every 3-6 months in women, and 4-5 months in men. This is a much longer interval than the daily, weekly or monthly dosing required for other hormone therapies. The slow steady release from the pellets leads to sustained effects over several months.

Enhanced Symptom Relief

Many patients report substantial improvements in menopausal and andropause symptoms including hot flashes, night sweats, sleep disturbances, mood swings, irritability, low libido, fatigue and lack of motivation when using pellet therapy. The constant hormone levels provided by the implants offer enhanced symptom relief compared to fluctuating options.

Increased Energy and Vitality

Balancing hormone levels leads to improved energy, stamina, mental clarity and an overall sense of wellbeing for both men and women. Many patients note feeling more energetic, productive and motivated when hormones are optimized through pellet therapy.


There is no daily dosing required with the pellets. This saves time and eliminates the need to remember to take pills, apply gels or change patches on a daily basis. The sustained delivery offers convenience and compliance compared to options that require more frequent dosing.

High Bioavailability

The hormones from the implant are absorbed efficiently into the bloodstream. This avoids poor absorption or breakdown associated with pills and topicals taken by mouth or applied to the skin. The pellets deliver a full dose of active hormones directly into circulation.

Embrace stability, vitality, and convenience with Hormone Pellet Therapy at Allure Medical – Transform your well-being today!

Risks and Side Effects of Hormone Pellets

While hormone pellet therapy provides many advantages, there are some potential risks and side effects to consider:

Insertion Site Reactions

Some pain, bruising, swelling or bleeding can occur at the site where the pellets are inserted. The risk of infection at the insertion site is low. Some patients may develop an allergic reaction to the pellets themselves.

Hormonal Side Effects

If hormone levels from the pellets become too high, patients may experience headaches, fluid retention, or a temporary increase in blood pressure. Estrogen pellet therapy can lead to breast tenderness, enlargement or sensitivity. Testosterone pellets may contribute to acne breakouts.

Stimulation of Estrogen-Sensitive Tissues

In patients with a history of endometriosis, hormone pellets containing estrogen may further stimulate the growth of this tissue. The risk of endometrial hyperplasia or uterine cancer may also be elevated in some cases. Patients should be screened and monitored appropriately.

Limited Adjustability

Once inserted, the hormone pellets begin releasing a steady dose of hormones. They cannot be easily removed or the dosing adjusted until they fully dissolve 3-6 months later. This differs from pills, patches or gels where dosing can be changed more rapidly if side effects occur.

Higher Upfront Cost

The insertion procedure and cost of the customized hormone pellets lead to a higher upfront cost compared to monthly prescriptions for pills, creams or patches. However, some of this cost may be offset by less frequent dosing.

Testing and Ongoing Monitoring

Regular lab testing and close medical supervision are recommended to monitor hormone levels and watch for potential side effects when using pellet therapy. This requires an investment of time and cost for office visits and lab work.

Hormone Pellet Insertion Procedure

The implantation process for hormone pellets is a quick and minimally invasive office procedure:

  1. We clean and sterilize the area on your body where the pellets will be inserted, typically the hip/buttock area. Our experts will then inject a local anesthetic to numb the area so you do not feel any pain during the procedure.
  2. Once numbed, we make a small incision in the skin, usually less than 1 centimeter long. Using a tool called an introducer, the hormone pellets will be inserted just under the subcutaneous tissue of the skin. The number of pellets inserted will depend on the dosage we determine based on your hormone needs.
  3. After the pellets are inserted, we may use dissolvable sutures to close the incision, or leave it to close on its own, depending on your preference. Our provider will apply a sterile bandage over the incision site to keep it clean as it heals.
  4. The effects of the localized anesthetic will wear off within a few hours after the procedure. Most patients report little to no pain afterwards. The incision site may be tender for a day or two as it heals.
  5. The hormone pellets will steadily dissolve and release hormones into your system over the next 3-6 months. When it is time to replace them, no removal is necessary. The remains of the old pellet implants will have completely dissolved and absorbed into the body.

The procedure will be repeated for replacements, with new pellets implanted either in the same location or the opposite side. This cycle continues as long as you wish to have pellet hormone therapy.

Experience precision and care during the Hormone Pellet Insertion Procedure with Allure Medical. Book now!

Are You a Candidate for Hormone Pellet Therapy?

Hormone pellets may benefit both men and women with low hormone levels who want to:

  • Alleviate hot flashes, night sweats and other menopause symptoms
  • Increase sex drive and energy
  • Improve sleep quality, mood and mental sharpness
  • Prevent bone loss or osteoporosis
  • Enhance overall wellbeing and vitality

Get in touch with our expert providers to find out if you might be a candidate for hormone pellet therapy. Blood tests help determine if your hormones are out of balance. If so, pellets could help restore optimal levels.

Schedule a Consultation for Hormone Pellet Therapy

If you struggle with symptoms of hormone imbalance, contact Allure Medical today to learn more about hormone pellet treatment. We offer complimentary consultations to assess if you are a candidate and answer all of your questions. Our experienced medical providers customize treatment plans to help you feel your best again.

In addition to hormone pellets, we offer a wide array of rejuvenating services including cosmetic procedures, injectables, body contouring, skin renewal, hair restoration, gynecology and wellness care.

Stop suffering and start feeling like yourself again! Call us at +18772558734 or book online to request your consultation.

Charles Mok

Dr. Charles Mok

About Charles Mok

Dr. Charles Mok received his medical degree from Chicago College of Osteopathic Medicine, Chicago, Illinois in 1989. He completed his medical residency at Mount Clemens General Hospital, Mt. Clemens, Michigan. He has worked with laser manufacturing companies to improve their technologies; he has performed clinical research studies and has taught physicians from numerous other states. His professionalism and personal attention to detail have contributed to the success of one of the first medical spas in Michigan.

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