How Long Does It Take for Hormone Pellets to Work?

A picture of Charles Mok

Charles Mok

Book Now
how long does it take for hormone pellets to work

Discover the Expected Timeline and When You Can Expect to Feel the Benefits

Wondering when hormone pellets start working? You may feel some effects in 1-3 days, but full results take 6-8 weeks after the pellets are inserted.

What Are Hormone Pellets and How Do They Work?

Hormone pellets, also called pellet implants, are very small capsules, about the size of a grain of rice, that are made of hormones like estrogen, testosterone, or thyroid hormone. The pellets are inserted just under the skin, usually around the hips, thighs or abdomen.

Once inserted, the hormone pellets dissolve slowly and release a steady dose of hormones into your system over the course of 3-6 months. The hormones get absorbed into your bloodstream providing your body with the right hormonal balance it needs.

The idea is that you maintain balanced hormone levels using the pellets, rather than the fluctuations you get from gels, pills or patches. The sustained release means you don’t have to apply gels or take pills every day.

Expected Timeline for Noticing Hormone Pellet Results

So how long does it take to feel the effects of hormone pellets after they’re inserted? Here’s a general timeline:

Time FrameExpected Results
Within 1-3 daysSome immediate effects like improved energy and mood, though not universal.
Within 1 weekBenefits such as better sleep and improved concentration may be felt.
Within 2-4 weeksSignificant relief of symptoms for which treatment is sought.
Within 6-8 weeksFull effects of hormone pellet therapy felt.
OngoingPellet implants last 3-6 months, requiring replacement for continued benefits.

As you can see, you’re likely to notice at least some positive changes within the first few days, but it will take 6-8 weeks to experience the full effects. The timeline varies based on the individual, which hormones you’re getting, health status, dosage, and other factors.

Influencing Factors on Speed of Hormone Pellet Effects

The timeline for seeing results from hormone pellet therapy depends on several influencing factors:


Results may take longer in older patients compared to younger ones.

Overall health

Those with certain medical conditions may have a delayed response.

Which hormones are used

Testosterone pellets act faster than estrogen or thyroid.

Prior hormone therapy

May respond faster if you have used hormone treatment before.

Dosage amount

Higher doses may produce effects sooner than lower doses.

Individual variation

We all respond differently based on health status and lifestyle.

So while most people start to see results within 1-3 weeks, your specific experience could be faster or slower. Work closely with your hormone specialist and be patient as your body regulates hormonal balance.

Quick-Onset Effects Within the First Week

Within the first 1-7 days after getting hormone pellet implants, many patients notice immediate improvements like:

  • Boost in energy and stamina
  • Feeling more motivated and productive
  • Improved quality of sleep
  • Balanced moods, less anxiety or irritability
  • Fewer hot flashes and night sweats if treating menopause
  • Better ability to focus and concentrate
  • Decrease in brain fog

These quick effects are likely related to the rise in hormonal levels and getting your hormones back into ideal balance. Even though the full effects take 6-8 weeks, these initial improvements can be very encouraging.

Longer-term Effects Felt Over 2 Months

Over the first 2 months, hormone pellets can provide significant relief from some of the most troublesome menopause, andropause or hypothyroidism symptoms:

  • Reduction in severity and frequency of hot flashes and night sweats
  • Decreased vaginal dryness and increased libido
  • Improved skin texture, thickness and elasticity
  • Increased energy for exercise, sports, and intimacy
  • Enhanced muscle mass and strength
  • Weight loss and inch loss, especially around the midsection
  • Sharper memory and improved mental clarity
  • Better moods and emotional stability
  • Deeper, more restorative sleep

These are just some of the beneficial effects you can expect over the first 8 weeks as your hormone levels regulate. Keep track of your symptoms and progress to see which ones improve for you.

Signs to Contact Your Hormone Specialist

While hormone pellets are very safe when administered properly, it’s important to contact your hormone specialist right away if you notice:

  • Unusual or severe side effects like rapid heartbeat, anxiety, or changes in vision
  • Pellet becoming visible as it extrudes from the skin
  • Increase in symptoms or new symptoms developing after 6 weeks
  • Significant pain, swelling, bruising, infection, or pus around the insertion site
  • Feel hormonal effects are too strong or not strong enough

Routine follow-up blood work and appointments are crucial to monitor your response. Your provider may make dosage adjustments based on your symptoms and lab results.


Hormone pellet therapy is a very effective method to restore hormonal balance and alleviate troublesome menopause, andropause and thyroid symptoms. While some positive effects are noticed right away, it takes a full 2 months to feel the complete benefits. Have patience as your body regulates hormone levels.

Work closely with your hormone specialist, get follow-up blood work done, and contact your provider if you have any concerns. Hormone pellets can vastly improve your quality of life when done properly under close medical supervision.

Charles Mok

Dr. Charles Mok

About Charles Mok

Dr. Charles Mok received his medical degree from Chicago College of Osteopathic Medicine, Chicago, Illinois in 1989. He completed his medical residency at Mount Clemens General Hospital, Mt. Clemens, Michigan. He has worked with laser manufacturing companies to improve their technologies; he has performed clinical research studies and has taught physicians from numerous other states. His professionalism and personal attention to detail have contributed to the success of one of the first medical spas in Michigan.

Read More